The Antimetabolite ara-CTP Blocks Long-Term Memory of Conditioned Taste Aversion
نویسندگان
چکیده
منابع مشابه
The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion.
We examined the hypothesis that processes related to DNA recombination and repair are involved in learning and memory. Rats received intracerebroventricular (i.c.v.) infusions of the antimetabolite 1-beta-D-arabinofuranosylcytosine triphosphate (ara-CTP) or its precursor cytosine arabinoside (ara-C) 30 min prior to conditioned taste aversion (CTA) training. Both ara-CTP and ara-C caused signifi...
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In the majority of studies designed to elucidate the causal mechanisms of memory formation, certain members of the experimental cohort, even though subjected to exactly the same conditioning procedures, remember significantly better than others, whereas others show little or no long-term memory (LTM) formation. To begin to address the question of why this phenomenon occurs and thereby help clar...
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These experiments explored the effects of glutamate, N-methyl-D-aspartate (NMDA) receptor blockade on the formation, retention, and expression of conditioned taste aversion (CTA) in young rats. Previous data from our laboratory suggested that ketamine administration potentiates a CTA in E18 rat fetuses. The current studies investigated this phenomenon in neonates. High-pressure liquid chromatog...
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Conditioned taste aversion (CTA) is an associative learning phenomenon in which ingestion of a novel tasting food or fluid (conditioned stimulus, CS) is paired with visceral malaise (unconditioned stimulus, US) (Yamamoto et al., 1994). Conditioned animals avoid ingesting the tastant previously associated with the condition of sickness. Since CTA is established by a single pairing of the CS and ...
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Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term depression (LTD) at mouse insular synapses. Genetic ablation and pharmacological inhibition of ASIC1a reduced the induction probability of LTD without affecting that of long-term potentiation in the insular cortex. The d...
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ژورنال
عنوان ژورنال: Learning & Memory
سال: 2003
ISSN: 1072-0502
DOI: 10.1101/lm.63003